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The rapid urbanization, industrialization, agricultural activities, and increasing trend of some natural hazards, such as climate change, particularly in coastal areas, necessitate the continual assessment of critical but fragile ecosystems like that of the Keta Lagoon Complex Ramsar Site (KLCRS). This productive ecosystem in Ghana faces serious threats from intensive exploitation, physical modification, changes in water regime, and water pollution. The current study employed geospatial and intensity analysis to assess the pattern of land use/land cover (LULC) change for almost the past three decades and morphometric parameters of the KLCRS landscape. Landsat Satellite images for 1991, 2007, and 2020 were acquired to uncover the pattern of LULC change, while morphometric changes were assessed using global Advance Space Thermal Emission and Radiometer (ASTER) digital elevation model (DEM) data and the spatial analyst tools in GIS software. The result established that the acceleration of land transformation was intensive between 2007 and 2020, which could be linked to population growth and increased socio-economic activities. There was a net gross gain of built-up that originated largely from the conversion of marsh, dense vegetation, and cultivated land. Prior to this period, cultivated land recorded net gain (125.51 km 2) between 1991 and 2007, whereas dense vegetation and marshland showed a net loss of 151.37 km 2 and 2.44 km 2, respectively. The gain of cultivated land largely targeted marshland in both time intervals. The construction of saltpans contributed largely to the small increase in water extent. The …