作者
Kongara M Reddy, Kevin Feris, Jason Bell, Denise G Wingett, Cory Hanley, Alex Punnoose
发表日期
2007/5/21
期刊
Applied physics letters
卷号
90
期号
21
出版商
AIP Publishing
简介
We report on the toxicity of ZnO nanoparticles (NPs) to gram-negative and gram-positive bacterial systems, Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus), and primary human immune cells. ZnO NP (∼ 13 nm) showed complete inhibition of E. coli growth at concentrations⩾ 3.4 mM, whereas growth of S. aureus was completely inhibited for⩾ 1 mM. Parallel experiments using flow cytometry based assays clearly demonstrated that growth inhibitory properties of ZnO NP were accompanied by a corresponding loss of cell viability. Identical ZnO NP had minimal effects on primary human T cell viability at concentrations toxic to both gram-negative and gram-positive bacteria. Collectively, these experiments demonstrate selectivity in the toxic nature of ZnO NP to different bacterial systems and human T lymphocytes. Developing selective toxicity to biological systems and controlling it by NP design could …
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KM Reddy, K Feris, J Bell, DG Wingett, C Hanley… - Applied physics letters, 2007