作者
Barbara Mc Cormack, N Maenhoudt, V Fincke, A Stejskalova, B Greve, L Kiesel, Gabriela Fabiana Meresman, H Vankelecom, M Götte, Rosa Ines Barañao
发表日期
2021/6/1
期刊
Human reproduction
卷号
36
期号
6
页码范围
1501-1519
出版商
Oxford University Press
简介
STUDY QUESTION
What are the effects of plant-derived antioxidant compounds urolithin A (UA) and B (UB) on the growth and pathogenetic properties of an in vitro endometriosis model?
SUMMARY ANSWER
Both urolithins showed inhibitory effects on cell behavior related to the development of endometriosis by differentially affecting growth, adhesion, motility, and invasion of endometriotic cells in vitro.
WHAT IS KNOWN ALREADY
Endometriosis is one of the most common benign gynecological diseases in women of reproductive age and is defined by the presence of endometrial tissue outside the uterine cavity. As current pharmacological therapies are associated with side effects interfering with fertility, we aimed at finding alternative therapeutics using natural compounds that can be administered for prolonged periods with a favorable side effects …
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B Mc Cormack, N Maenhoudt, V Fincke, A Stejskalova… - Human reproduction, 2021
