作者
Christopher I van de Wetering, Mitchell C Coleman, Douglas R Spitz, Brian J Smith, C Michael Knudson
发表日期
2008/4/15
期刊
Free Radical Biology and Medicine
卷号
44
期号
8
页码范围
1677-1686
出版商
Pergamon
简介
Increased reactive oxygen species (ROS) such as superoxide have been implicated as causal elements of oncogenesis. A variety of cancers have displayed changes in steady-state levels of key antioxidant enzymes, with the mitochondrial form of superoxide dismutase (MnSOD) being commonly implicated. Increasing MnSOD expression suppresses the malignant phenotype in various cancer cell lines and suppresses tumor formation in xenograft and transgenic mouse models. We examined the impact of MnSOD expression in the development of T cell lymphoma in mice expressing proapoptotic Bax. Lck-Bax38/1 transgenic mice were crossed to mice overexpressing MnSOD (Lck-MnSOD) as well as MnSOD+/− mice. The effects of MnSOD on apoptosis, cell cycle, chromosomal instability (CIN), and lymphoma development were determined. The apoptotic and cell cycle phenotypes observed in thymocytes from …
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CI van de Wetering, MC Coleman, DR Spitz, BJ Smith… - Free Radical Biology and Medicine, 2008