作者
RZ Goldstein, PA Woicik, SJ Moeller, F Telang, M Jayne, C Wong, GJ Wang, JS Fowler, ND Volkow
发表日期
2010/2
期刊
Journal of psychopharmacology
卷号
24
期号
2
页码范围
257-266
出版商
Sage Publications
简介
Few studies have examined the subjective value attributed to drug rewards specifically as it compares with the value attributed to primary non-drug rewards in addicted individuals. The objective of this study is to assess ‘liking’ and ‘wanting’ of expected ‘drug’ rewards as compared to ‘food’ and ‘sex’ while respondents report about three different situations (‘current’, and hypothetical ‘in general’, and ‘under drug influence’). In all, 20 cocaine-addicted individuals (mean abstinence = 2 days) and 20 healthy control subjects were administered the STRAP-R (Sensitivity To Reinforcement of Addictive and other Primary Rewards) questionnaire after receiving an oral dose of the dopamine agonist methylphenidate (20 mg) or placebo. The reinforcers’ relative value changed within the addicted sample when reporting about the ‘under drug influence’ situation (drug > food; otherwise, drug < food). This change was highest in …
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