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Sea-level history in the Red Sea region has commonly been interpreted as an accurate proxy for global mean sea level (GMSL), which can be used to constrain global ice volumes and inform a diverse range of regional paleoclimate studies. Previous modeling work has demonstrated, however, that glacial isostatic adjustment (GIA) processes may introduce significant departures from GMSL in this region. The GIA signal is a complex combination of deformational, gravitational, and rotational effects arising from shifting ice and water surface loads and consists of long-wavelength effects superimposed by a short-wavelength signal associated with “continental levering” – a response to local meltwater loading. In this study, we revisit the effects of GIA in the Red Sea region using Earth models characterized by 3-D variations in mantle viscoelastic structure and lithospheric thickness, focusing on the period from Last …