作者
Akhgar Ghassabian, Hanan El Marroun, Robin P Peeters, Vincent W Jaddoe, Albert Hofman, Frank C Verhulst, Henning Tiemeier, Tonya White
发表日期
2014/7/1
期刊
The Journal of Clinical Endocrinology & Metabolism
卷号
99
期号
7
页码范围
2383-2390
出版商
Oxford University Press
简介
Context
Although maternal hypothyroxinemia is suggested to be related to various adverse consequences in a child's neurodevelopment, the underlying neurobiology is largely unknown.
Objective
The objective of the study was to examine the relationship between maternal hypothyroxinemia in early pregnancy and children's nonverbal intelligence quotient (IQ). Furthermore, we explored whether global brain volumes, cortical thickness, and brain surface area differed between children exposed prenatally to hypothyroxinemia and healthy controls.
Design and Setting
The study included a large population-based prospective birth cohort in The Netherlands.
Participants
A total of 3727 mother-child pairs with data on prenatal thyroid function at less than 18 weeks of gestation and nonverbal IQ at 6 years participated in the study. In 652 children …
学术搜索中的文章
A Ghassabian, H El Marroun, RP Peeters, VW Jaddoe… - The Journal of Clinical Endocrinology & Metabolism, 2014