作者
Laura ME Blanken, Sabine E Mous, Akhgar Ghassabian, Ryan L Muetzel, Nikita K Schoemaker, Hanan El Marroun, Aad van der Lugt, Vincent WV Jaddoe, Albert Hofman, Frank C Verhulst, Henning Tiemeier, Tonya White
发表日期
2015/5/1
期刊
American Journal of Psychiatry
卷号
172
期号
5
页码范围
479-486
出版商
American Psychiatric Association
简介
Objective
Recent evidence suggests that symptoms of social impairment in autism spectrum disorder (ASD) form a spectrum that extends into the general population. However, it is unclear whether the neuroanatomy of ASD also shows a similar continuum in the general population. Therefore, the goal of the present study was to investigate the relationship between cortical morphology and autistic traits along a continuum in a large population-based sample of young children.
Method
The study included 717 children, aged 6–10 years, who are participants in the Generation R Study, a large population-based cohort. Autistic traits were measured using the Social Responsiveness Scale when the children were approximately 6 years old. High-resolution MRI was obtained, and morphological measures of the cortex, including cortical thickness and gyrification, were quantified brain-wide.
Results
Children with more autistic …
学术搜索中的文章
LME Blanken, SE Mous, A Ghassabian, RL Muetzel… - American Journal of Psychiatry, 2015