作者
AM James Shapiro, Camillo Ricordi, Bernhard J Hering, Hugh Auchincloss, Robert Lindblad, R Paul Robertson, Antonio Secchi, Mathias D Brendel, Thierry Berney, Daniel C Brennan, Enrico Cagliero, Rodolfo Alejandro, Edmond A Ryan, Barbara DiMercurio, Philippe Morel, Kenneth S Polonsky, Jo-Anna Reems, Reinhard G Bretzel, Federico Bertuzzi, Tatiana Froud, Raja Kandaswamy, David ER Sutherland, George Eisenbarth, Miriam Segal, Jutta Preiksaitis, Gregory S Korbutt, Franca B Barton, Lisa Viviano, Vicki Seyfert-Margolis, Jeffrey Bluestone, Jonathan RT Lakey
发表日期
2006/9/28
期刊
New England Journal of Medicine
卷号
355
期号
13
页码范围
1318-1330
出版商
Massachusetts Medical Society
简介
Background
Islet transplantation offers the potential to improve glycemic control in a subgroup of patients with type 1 diabetes mellitus who are disabled by refractory hypoglycemia. We conducted an international, multicenter trial to explore the feasibility and reproducibility of islet transplantation with the use of a single common protocol (the Edmonton protocol).
Methods
We enrolled 36 subjects with type 1 diabetes mellitus, who underwent islet transplantation at nine international sites. Islets were prepared from pancreases of deceased donors and were transplanted within 2 hours after purification, without culture. The primary end point was defined as insulin independence with adequate glycemic control 1 year after the final transplantation.
Results
Of the 36 subjects, 16 (44%) met the primary end point, 10 (28%) had partial function, and 10 (28%) had complete graft loss 1 year after the final transplantation. A …
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