作者
Quing Zhu, Minming Huang, NanGuang Chen, Kristen Zarfos, Bipin Jagjivan, Mark Kane, Poornima Hedge, Scott H Kurtzman
发表日期
2003/9/1
期刊
Neoplasia
卷号
5
期号
5
页码范围
379-388
出版商
Elsevier
简介
The diagnosis of solid benign and malignant tumors presents a unique challenge to all noninvasive imaging modalities. Ultrasound is used in conjunction with mammography to differentiate simple cysts from solid lesions. However, the overlapping appearances of benign and malignant lesions make ultrasound less useful in differentiating solid lesions, resulting in a large number of benign biopsies. Optical tomography using near-infrared diffused light has great potential for imaging functional parameters of 1) tumor hemoglobin concentration, 2) oxygen saturation, 3) metabolism, as well as other tumor distinguishing characteristics. These parameters can differentiate benign from malignant lesions. However, optical tomography, when used alone, suffers from low spatial resolution and target localization uncertainty due to intensive light scattering. Our aim is to combine diffused light imaging with ultrasound in a novel …
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Q Zhu, M Huang, NG Chen, K Zarfos, B Jagjivan… - Neoplasia, 2003