作者
Pradip Sen, Mark A Wallet, Zuoan Yi, Yingsu Huang, Michael Henderson, Clayton E Mathews, H Shelton Earp, Glenn Matsushima, Albert S Baldwin Jr, Roland M Tisch
发表日期
2007/1/15
期刊
Blood
卷号
109
期号
2
页码范围
653-660
出版商
American Society of Hematology
简介
Dendritic cells (DCs) play a key role in immune homeostasis and maintenance of self-tolerance. Tolerogenic DCs can be established by an encounter with apoptotic cells (ACs) and subsequent inhibition of maturation and effector functions. The receptor(s) and signaling pathway(s) involved in AC-induced inhibition of DCs have yet to be defined. We demonstrate that pretreatment with apoptotic but not necrotic cells inhibits activation of IκB kinase (IKK) and downstream NF-κB. Notably, receptor tyrosine kinase Mer (MerTK) binding of ACs is required for mediating this effect. Monocyte-derived DCs lacking MerTK expression (MerTKKD) or treated with blocking MerTK-specific antibodies (Abs) are resistant to AC-induced inhibition and continue to activate NF-κB and secrete proinflammatory cytokines. Blocking MerTK activation of the phosphatidylinositol 3-kinase (PI3K)/AKT pathway prevents AC-induced inhibition …
引用总数
学术搜索中的文章
Apoptotic cells induce Mer tyrosine kinase–dependent blockade of NF-κB activation in dendritic cells
P Sen, MA Wallet, Z Yi, Y Huang, M Henderson… - Blood, 2007