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We present a constraint-based routing (CBR) approach for real-time operation considering both linear as well as nonlinear signal quality degrading effects in a heterogeneous network infrastructure. Different novel routing algorithms are assessed regarding their blocking probabilities. Furthermore, regenerator pools are placed at a limited number of nodes selected by a heuristic algorithm taking into account the physical impairments. It is shown that CBR together with intelligent regenerator placement can decrease the blocking probability significantly.