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An incessant upsurge in the use of chemical fertilizers has led to several disastrous effects on agriculture and environment. Biological control has provided a plausible alternative to lower down the usage of chemical fertilizers. Plant associated microorganisms play an important role in sustainable agriculture for enhancing plant growth, productivity as well as stress amelioration. Endophytic microbes, residing in plant play a powerful role in exerting their beneficial attributes with a higher consistency, particularly since they dwell in a relatively secure environment, largely protected from the externally induced abiotic/biotic stresses. However, irrespective of the multi-faceted benefits of endophytic bacteria, the role of these microbes in agriculture still remains unrealized and unexploited. In this work, we have described the endophyte-plant interactions taking into consideration the several aspects of endophytic activity to enhance awareness towards the application of endophytic bacteria in organic farming.