作者
Ivona Baricevic, Xiaotong He, Bipasha Chakrabarty, Anthony W Oliver, Charles Bailey, Jeff Summers, Lynne Hampson, Ian Hampson, Duncan C Gilbert, Andrew G Renehan
发表日期
2015/4/1
期刊
European journal of cancer
卷号
51
期号
6
页码范围
776-785
出版商
Pergamon
简介
Background
Characterisation of human papilloma virus (HPV) infection in anal squamous cell carcinoma (ASCC) may have dual importance: first, aetiological; second, prognostic, informing outcome after chemo-radiotherapy (CRT). We undertook HPV genotyping, and allelic characterisations, to evaluate the aetiological role of HPV while simultaneously evaluating the impact of HPV genotyping on relapse-free (RFS) and overall survival (OS).
Method
Dual-primer HPV genotyping (subtypes 6, 11, 16, 18, 31, 33, 45, 52, 58) and DNA sequencing of HPV 16 positive tumours were analysed in 151 consecutively referred ASCCs, previously characterised by immunohistochemistry for p16 expression. In 110 patients treated with CRT, factors influencing RFS and OS were evaluated using univariate and multivariate models.
Results
HPV positivity was observed in 95%. HPV 16 accounted for 89%; of these, 64% harboured the …
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I Baricevic, X He, B Chakrabarty, AW Oliver, C Bailey… - European journal of cancer, 2015