作者
Laura Bonanni, Bernardo Perfetti, Stefania Bifolchetti, John-Paul Taylor, Raffaella Franciotti, Lucilla Parnetti, Astrid Thomas, Marco Onofrj
发表日期
2015/1/1
期刊
Neurobiology of aging
卷号
36
期号
1
页码范围
434-445
出版商
Elsevier
简介
Mild cognitive impairment (MCI) as a precursor of dementia with Lewy bodies (DLB) is the focus of recent research, trying to explore the early mechanisms and possible biomarkers of DLB. Quantitative electroencephalogram (QEEG) methods are able to differentiate early DLB from Alzheimer's disease (AD). The aim of the present study was to assess whether QEEG abnormalities, characterized by dominant frequency <8 Hz and dominant frequency variability >1.5 Hz, typical of early DLB, are already present at the stage of MCI and to evaluate whether EEG abnormalities can predict the development of DLB. Forty-seven MCI subjects were followed for 3 years. EEG recordings were obtained at admission and at the end of the study. At the end of follow-up, 20 subjects had developed probable DLB (MCI-DLB), 14 had probable AD (MCI-AD), 8 did not convert to dementia, 5 developed a non-AD/DLB dementia. One …
引用总数
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