作者
Rachael A Lawson, Alison J Yarnall, Gordon W Duncan, David P Breen, Tien K Khoo, Caroline H Williams-Gray, Roger A Barker, Daniel Collerton, John-Paul Taylor, David J Burn, ICICLE-PD study group
发表日期
2016/6/1
期刊
Parkinsonism & related disorders
卷号
27
页码范围
47-53
出版商
Elsevier
简介
Introduction
Parkinson's disease dementia (PDD) is associated with poorer quality of life (QoL). Prior to the onset of PDD, many patients experience progressive cognitive impairment. There is a paucity of longitudinal studies investigating the effects of cognitive decline on QoL. This study aimed to determine the longitudinal impact of cognitive change on QoL in an incident PD cohort.
Methods
Recently diagnosed patients with PD (n = 212) completed a schedule of neuropsychological assessments and QoL measures; these were repeated after 18 (n = 190) and 36 months (n = 158). Mild cognitive impairment (PD-MCI) was classified with reference to the Movement Disorder Society criteria. Principal component analysis was used to reduce 10 neuropsychological tests to three cognitive factors: attention, memory/executive function, and global cognition.
Results
Baseline PD-MCI was a significant contributor to QoL (β = 0.2 …
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RA Lawson, AJ Yarnall, GW Duncan, DP Breen… - Parkinsonism & related disorders, 2016