作者
Alvar Agusti, Peter MA Calverley, Bartolome Celli, Harvey O Coxson, Lisa D Edwards, David A Lomas, William MacNee, Bruce E Miller, Steve Rennard, Edwin K Silverman, Ruth Tal-Singer, Emiel Wouters, Julie C Yates, Jørgen Vestbo, Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE) investigators
发表日期
2010/12
期刊
Respiratory research
卷号
11
页码范围
1-14
出版商
BioMed Central
简介
Background
Chronic obstructive pulmonary disease (COPD) is a complex condition with pulmonary and extra-pulmonary manifestations. This study describes the heterogeneity of COPD in a large and well characterised and controlled COPD cohort (ECLIPSE).
Methods
We studied 2164 clinically stable COPD patients, 337 smokers with normal lung function and 245 never smokers. In these individuals, we measured clinical parameters, nutritional status, spirometry, exercise tolerance, and amount of emphysema by computed tomography.
Results
COPD patients were slightly older than controls and had more pack years of smoking than smokers with normal lung function. Co-morbidities were more prevalent in COPD patients than in controls, and occurred to the same extent irrespective of the GOLD stage. The severity of …
引用总数
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