作者
Dave Singh, Alvar Agusti, Antonio Anzueto, Peter J Barnes, Jean Bourbeau, Bartolome R Celli, Gerard J Criner, Peter Frith, David MG Halpin, Meilan Han, M Victorina López Varela, Fernando Martinez, Maria Montes de Oca, Alberto Papi, Ian D Pavord, Nicolas Roche, Donald D Sin, Robert Stockley, Jørgen Vestbo, Jadwiga A Wedzicha, Claus Vogelmeier
发表日期
2019/5/1
来源
European Respiratory Journal
卷号
53
期号
5
出版商
European Respiratory Society
简介
Precision medicine is a patient-specific approach that integrates all relevant clinical, genetic and biological information in order to optimise the therapeutic benefit relative to the possibility of side-effects for each individual. Recent clinical trials have shown that higher blood eosinophil counts are associated with a greater efficacy of inhaled corticosteroids (ICSs) in chronic obstructive pulmonary disease (COPD) patients. Blood eosinophil counts are a biomarker with potential to be used in clinical practice, to help target ICS treatment with more precision in COPD patients with a history of exacerbations despite appropriate bronchodilator treatment.
The Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2017 pharmacological treatment algorithms, based on the ABCD assessment, can be applied relatively easily to treatment-naive individuals at initial presentation. However, their use is more problematic during …
学术搜索中的文章
D Singh, A Agusti, A Anzueto, PJ Barnes, J Bourbeau… - European Respiratory Journal, 2019