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Despite the tremendous success obtained using the current pharmacotherapy, especially angiotensin (Ang)-converting enzyme (ACE) inhibitors (ACEis) and Ang II receptor blockers (ARBs), the prevalence of cardiovascular diseases (CVDs) remains high around the world. The overall death rate in the United States alone in 2005 was 278.9 per 100 000 people. 1 These unprecedented numbers have stimulated researchers to consider the development of new strategies and targets to control these diseases. Since its discovery, the renin-Ang system (RAS) has been considered an important target to manage the disturbances of the cardiovascular system. In fact, RAS blockers represent the main class of drugs in the treatment of hypertension and CVDs. 2 Recent genomic and proteomic studies have led to significant advances in our understanding of the RAS and in experimental methods for studying regulatory …