作者
Vinayak Shenoy, Anderson J Ferreira, Yanfei Qi, Rodrigo A Fraga-Silva, Carlos Díez-Freire, Autumn Dooies, Joo Yun Jun, Srinivas Sriramula, Nithya Mariappan, Dorna Pourang, Changaram S Venugopal, Joseph Francis, Timothy Reudelhuber, Robson A Santos, Jawaharlal M Patel, Mohan K Raizada, Michael J Katovich
发表日期
2010/10/15
期刊
American journal of respiratory and critical care medicine
卷号
182
期号
8
页码范围
1065-1072
出版商
American Thoracic Society
简介
Rationale: An activated vasoconstrictive, proliferative, and fibrotic axis of the renin angiotensin system (angiotensin-converting enzyme [ACE]/angiotensin [Ang]II/AngII type 1 receptor) has been implicated in the pathophysiology of pulmonary fibrosis (PF) and pulmonary hypertension (PH). The recent discovery of a counterregulatory axis of the renin angiotensin system composed of ACE2/Ang-(1–7)/Mas has led us to examine the role of this vasoprotective axis on such disorders.
Objectives: We hypothesized that Ang-(1–7) treatment would exert protective effects against PF and PH.
Methods: Lentiviral packaged Ang-(1–7) fusion gene or ACE2 cDNA was intratracheally administered into the lungs of male Sprague Dawley rats. Two weeks after gene transfer, animals received bleomycin (2.5 mg/kg). In a subsequent study, animals were administered monocrotaline (MCT, 50 mg/kg).
Measurements and Main Results: In …
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