作者
Cameron Brennan, T Jonathan Yang, Patrick Hilden, Zhigang Zhang, Kelvin Chan, Yoshiya Yamada, Timothy A Chan, Stella C Lymberis, Ashwatha Narayana, Viviane Tabar, Philip H Gutin, Åse Ballangrud, Eric Lis, Kathryn Beal
发表日期
2014/1/1
期刊
International Journal of Radiation Oncology* Biology* Physics
卷号
88
期号
1
页码范围
130-136
出版商
Elsevier
简介
Purpose
To evaluate local control after surgical resection and postoperative stereotactic radiosurgery (SRS) for brain metastases.
Methods and Materials
A total of 49 patients (50 lesions) were enrolled and available for analysis. Eligibility criteria included histologically confirmed malignancy with 1 or 2 intraparenchymal brain metastases, age ≥18 years, and Karnofsky performance status (KPS) ≥70. A Cox proportional hazard regression model was used to test for significant associations between clinical factors and overall survival (OS). Competing risks regression models, as well as cumulative incidence functions, were fit using the method of Fine and Gray to assess the association between clinical factors and both local failure (LF; recurrence within surgical cavity or SRS target), and regional failure (RF; intracranial metastasis outside of treated volume).
Results
The median follow-up was 12.0 months (range, 1.0-94 …
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C Brennan, TJ Yang, P Hilden, Z Zhang, K Chan… - International Journal of Radiation Oncology* Biology …, 2014