作者
T Jonathan Yang, Monica Morrow, Shanu Modi, Zhigang Zhang, Kate Krause, Chun Siu, Beryl McCormick, Simon N Powell, Alice Y Ho
发表日期
2015/12
期刊
Annals of surgical oncology
卷号
22
页码范围
495-501
出版商
Springer US
简介
Background
The relative contribution of biologic subtype to locoregional recurrence (LRR) in patients treated with neoadjuvant chemotherapy (NAC), mastectomy, and postmastectomy radiotherapy (PMRT) is not clearly defined.
Methods
233 patients with stages 2 and 3 breast cancer who received NAC, mastectomy, and PMRT between 2000 and 2009 were included: 53 % (n = 123) had HR+ (ER or PR+/HER2−), 23 % (n = 53) had HER2+ (HER2+/HR+ or HR−), and 24 % (n = 57) had triple-negative (TN) disease (HR−/HER2−). The 5-year LRR rates were estimated by Kaplan–Meier methods. Cox regression analysis was performed to evaluate covariates associated with LRR.
Results
The median follow-up period was 62 months. A pathologic complete response (pCR) was seen in 14 % of the patients. The 5-year LRR …
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TJ Yang, M Morrow, S Modi, Z Zhang, K Krause, C Siu… - Annals of surgical oncology, 2015
