作者
Nuno Rodrigues Faria, Moritz UG Kraemer, Sarah C Hill, Jaqueline Góes de Jesus, RS de Aguiar, Felipe CM Iani, Joilson Xavier, Josh Quick, Louis du Plessis, Simon Dellicour, Julien Thézé, RDO Carvalho, Guy Baele, C-H Wu, Paola P Silveira, MB Arruda, MA Pereira, G d C Pereira, José Lourenço, Uri Obolski, L Abade, TI Vasylyeva, M Giovanetti, D Yi, DJ Weiss, GRW Wint, FM Shearer, Shelby Funk, B Nikolay, V Fonseca, TER Adelino, MAA Oliveira, MVF Silva, L Sacchetto, PO Figueiredo, IM Rezende, EM Mello, RFC Said, DA Santos, ML Ferraz, MG Brito, LF Santana, MT Menezes, RM Brindeiro, A Tanuri, FCP Dos Santos, Margarida S Cunha, JS Nogueira, IM Rocco, AC Da Costa, SCV Komninakis, V Azevedo, AO Chieppe, ESM Araujo, MCL Mendonça, CC Dos Santos, CD Dos Santos, AM Mares-Guia, RMR Nogueira, PC Sequeira, RG Abreu, MHO Garcia, AL Abreu, O Okumoto, Erna Geessien Kroon, CFC De Albuquerque, K Lewandowski, ST Pullan, Miles Carroll, T De Oliveira, EC Sabino, RP Souza, Marc A Suchard, Philippe Lemey, GS Trindade, BP Drumond, AMB Filippis, NJ Loman, Simon Cauchemez, LCJ Alcantara, Oliver George Pybus
发表日期
2018/8/31
期刊
Science
卷号
361
期号
6405
页码范围
894-899
出版商
American Association for the Advancement of Science
简介
The yellow fever virus (YFV) epidemic in Brazil is the largest in decades. The recent discovery of YFV in Brazilian Aedes species mosquitos highlights a need to monitor the risk of reestablishment of urban YFV transmission in the Americas. We use a suite of epidemiological, spatial, and genomic approaches to characterize YFV transmission. We show that the age and sex distribution of human cases is characteristic of sylvatic transmission. Analysis of YFV cases combined with genomes generated locally reveals an early phase of sylvatic YFV transmission and spatial expansion toward previously YFV-free areas, followed by a rise in viral spillover to humans in late 2016. Our results establish a framework for monitoring YFV transmission in real time that will contribute to a global strategy to eliminate future YFV epidemics.
学术搜索中的文章
NR Faria, MUG Kraemer, SC Hill, J Góes de Jesus… - Science, 2018
