作者
Vaios Svolos, Richard Hansen, Ben Nichols, Christopher Quince, Umer Z Ijaz, Rodanthi T Papadopoulou, Christine A Edwards, David Watson, Adel Alghamdi, Asker Brejnrod, Cecilia Ansalone, Hazel Duncan, Lisa Gervais, Rachel Tayler, Jonathan Salmond, Daniele Bolognini, Robert Klopfleisch, Daniel R Gaya, Simon Milling, Richard K Russell, Konstantinos Gerasimidis
发表日期
2019/4/1
期刊
Gastroenterology
卷号
156
期号
5
页码范围
1354-1367. e6
出版商
WB Saunders
简介
Background & Aims
Exclusive enteral nutrition (EEN) is the only established dietary treatment for Crohn's disease (CD), but its acceptability is limited. There is a need for novel dietary treatments for CD.
Methods
We evaluated the effects of an individualized food-based diet (CD-TREAT), with similar composition to EEN, on the gut microbiome, inflammation, and clinical response in a rat model, healthy adults, and children with relapsing CD. Twenty-five healthy adults randomly received EEN or CD-TREAT for 7 days, followed by a 14-day washout period, followed by the alternate diet. Fecal microbiome and metabolome were assessed before and after each diet. HLA-B7 and HLA-B27 transgenic rats with gut inflammation received EEN, CD-TREAT, or standard chow for 4 weeks. Fecal, luminal, and tissue microbiome, fecal metabolites, and gut inflammation were assessed. Five children with active CD activity received …
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V Svolos, R Hansen, B Nichols, C Quince, UZ Ijaz… - Gastroenterology, 2019
