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As part of the development of DSM-5, the Cultural Formulation Interview (CFI) was administered to 30 monolingual Spanish-speaking adults at one site of a 2012 feasibility study of the CFI. The authors identified salient themes in data collected through use of the CFI, with a focus on interventions that could lead to more culturally responsive mental health services. Findings suggest that establishing trust and focusing on the restoration of social ties while attending to the impact of stigma and patients’ pressing psychosocial needs are elements of culturally responsive services for Hispanic persons. Routine use of the CFI can help clinicians identify unique needs and preferences by understanding an individual within his or her cultural context.