作者
Yan Li, Benedikt Schaarschmidt, Lale Umutlu, Michael Forsting, Aydin Demircioglu, Anna Katharina Koch, Ole Martin, Ken Herrmann, Hendrik Juette, Andrea Tannapfel, Jost Langhorst
发表日期
2020/4
期刊
European Journal of Nuclear Medicine and Molecular Imaging
卷号
47
页码范围
768-777
出版商
Springer Berlin Heidelberg
简介
Purpose
To evaluate the diagnostic performance of PET-MR enterography in detecting histological active inflammation in patients with ulcerative colitis and the impact of bowel purgation on diagnostic accuracies of PET-MR parameters.
Methods
Fifty patients were enrolled in this randomized controlled trial (clinicaltrials.gov [NCT03781284]). Forty patients were randomized in two study arms, in which bowel purgation was performed either before or after PET-MR enterography. All patients underwent ileocolonoscopy with mucosal biopsies after PET-MR within 24 h. Diagnostic performance of MR morphological parameters (MRmorph), diffusion-weighted imaging (DWI), and PET in detecting histological inflammation determined by the Nancy index was compared with each other and between study arms. Correlation between PET and histological inflammatory severity was calculated.
Results
In study arm without …
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