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Objective:

We aimed to report long-term outcomes for patients undergoing per-oral endoscopic myotomy (POEM) after our initial 15-case learning curve.

Background:

POEM has become an established, natural-orifice surgical approach for treating esophageal motility disorders. To date, published outcomes and comparative-effectiveness studies have included patients from the early POEM experience.

Methods:

Consecutive patients undergoing POEM after our initial 15 cases, with a minimum of 1-year postoperative follow-up, were included. Treatment success was defined as an Eckardt score≤ 3 without reintervention. Gastroesophageal reflux was defined by abnormal pH-testing or reflux esophagitis> Los Angeles grade A.

Results:

Between January 2012 and March 2015, 115 patients underwent POEM at a single, high-volume center. Operative time was 101±29 minutes, with 95%(109/115) of patients discharged on …