作者
Zu‐In Su, Jennifer Wenzel, Aaron Ettenberg, Osnat Ben‐Shahar
发表日期
2014/9
期刊
Addiction biology
卷号
19
期号
5
页码范围
826-837
简介
We have previously shown that extended‐access subjects exhibit heightened motivation for cocaine in the runway model, as reflected by reduced number of retreats. This heightened motivation could reflect either an increase in cocaine‐induced reward or a decrease in cocaine‐induced aversion. The current experiment was therefore devised to assess the cocaine‐induced reward and aversion in extended‐access rats using a place conditioning test. Rats trained to lever press for intravenous (IV) cocaine (0.25 mg/infusion) were provided 6‐hour daily access to the drug over 10 days. Lever pressing in control subjects produced IV infusions of saline. Following drug self‐administration, subjects underwent place conditioning for the immediate or delayed effects of cocaine (1.0 or 2.5 mg/kg, IV). In control subjects, the immediate effects of the low dose of cocaine produced conditioned places preferences (CPPs …
引用总数
20142015201620172018201923311