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Global climate change associated with increasing temperature and unreliable rainfall events will have consequences for crop production. Therefore, strategizing crop management gained the attention of crop scientists to curtail the adverse impacts of climate change on crop production. However, the projected effects of climate change on wheat may vary in different cropping systems as wheat production is reported to be significantly impacted by future climate change in major cropping systems worldwide. In the present study, ten experiments were conducted under irrigated (2007–2013) and rainfed (2010–2014) cropping systems of Pakistan to quantify the interactive impacts of future climate change (CO₂, temperature, and rainfall) on wheat phenology, grain yield, crop evapotranspiration (ET_c), and water use efficiency (WUE) using the DSSAT-CERES-Wheat. The DSSAT-CERES-Wheat was executed using 17 …