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COI notes: Dr. Loh has served as a consultant to Pfizer and Seattle Genetics and has received honoraria from Pfizer. Dr. Leblanc reports the following: personal fees for consulting or advisory boards from AbbVie, Agios, AstraZeneca, Amgen, Astellas, CareVive, BMS/Celgene, Daiichi-Sankyo, Heron, Flatiron, Pfizer, and Seattle Genetics; royalties from UpToDate; speakers bureau fees from Agios, AbbVie, and BMS/Celgene; grants and/or research contracts from the American Cancer Society, AstraZeneca, BMS, Jazz Pharmaceuticals, the NINR/NIH, and Seattle Genetics. Dr. Wong reports conflicts of interest outside of the submitted work (royalties from UpToDate, immediate family member is an employee of Genentech with stock ownership). All other authors have no relevant conflicts of interest to report.