作者
Joseph A Hill, Katalin Polgar, Deborah J Anderson
发表日期
1995/6/28
期刊
Jama
卷号
273
期号
24
页码范围
1933-1936
出版商
American Medical Association
简介
Objective
—To test the hypothesis that peripheral blood mononuclear cells in women with unexplained recurrent abortion (URA) produce T-helper 1 (TH1)—type cytokines in response to trophoblast antigens.
Design
—Cohort study.
Setting
—Medical center.
Participants
—A total of 244 women with URA, 13 reproductively normal parous control women, and 10 men.
Main Outcome Measures
—Supernatants from trophoblast-activated peripheral blood mononuclear cells from all participants were tested for toxic effects on mouse embryos and by enzyme-linked immunosorbent assay (ELISA) for interferon gamma (IFN-γ). Supernatants from 20 URA patients with embryotoxic activity and IFN-γ, 13 reproductively normal parous women, and 10 men were further tested by ELISA for other TH1-type cytokines (interleukin-2 [IL-2], tumor necrosis factor—β [TNF-β]), TH2-type cytokines (IL-4, IL-10), and TNF-α.
Results
—Embryotoxic …
引用总数
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学术搜索中的文章
JA Hill, K Polgar, DJ Anderson - Jama, 1995