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Objectives. To assess the efficacy and safety of nicardipine in comparison to labetalol in the initial management of severe hypertension in pregnancy.

Design. Randomized prospective study.

Setting. The obstetric ward of the teaching hospital of Monastir Tunisia.

Patients. Sixty consecutive pregnant women admitted beyond the 24th week of pregnancy with severe hypertension.

Intervention. Patients were randomly assigned to receive intravenously for 1 h either labetalol (n=30) or nicardipine (n=30). Treatment was titrated to achieve a 20% lowering of blood pressure (BP).

Measurements. Maternal BP and heart rate were measured at inclusion and repeatedly during the first hour following the drugs administration. Fetal heart rate was recorded throughout the study period. The main outcome endpoints were the …