作者
April P De Silva, Mark A Schembri, Angus H Sarah, Jessica Chao, Kwok Ho Yip, Gökhan Cildir, Angel Lopez, Damon J Tumes, Harshita Pant
发表日期
2021/10
期刊
The Laryngoscope
卷号
131
期号
10
页码范围
E2618-E2626
出版商
John Wiley & Sons, Inc.
简介
Objectives/Hypothesis
The efficacy of short‐term oral corticosteroids in chronic rhinosinusitis without nasal polyps (CRSsNP) is unknown. The aim of this controlled study was to assess the immediate and long‐term outcomes from a short course of a commonly used oral corticosteroid, prednisolone, in well‐defined CRSsNP patients.
Study Design
Prospective, observational controlled study.
Methods
A prospective‐controlled study of CRSsNP patients treated with prednisolone at 0.5 mg/kg tapered over 10 days and non‐prednisolone treated CRSsNP patients (controls) and follow‐up at 2, 6, and 12 months. Baseline and follow‐up SinoNasal Outcome Test (SNOT)‐22, nasal endoscopy (Lund‐Kennedy), and sinus CT scan scores (Lund‐Mackay) were compared.
Results
At 2 months, there was a significant improvement in the SNOT‐22, nasal endoscopy, and sinus CT scan scores in the prednisolone group …
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AP De Silva, MA Schembri, AH Sarah, J Chao, KH Yip… - The Laryngoscope, 2021