作者
Pauline Arends, Milan J Sonneveld, Roeland Zoutendijk, Ivana Carey, Ashley Brown, Massimo Fasano, David Mutimer, Katja Deterding, Jurriën GP Reijnders, Ye Oo, Jörg Petersen, Florian Van Bömmel, Robert J De Knegt, Teresa Santantonio, Thomas Berg, Tania M Welzel, Heiner Wedemeyer, Maria Buti, Pierre Pradat, Fabien Zoulim, Bettina Hansen, Harry LA Janssen
发表日期
2015/8/1
期刊
Gut
卷号
64
期号
8
页码范围
1289-1295
出版商
BMJ Publishing Group
简介
Background
Hepatocellular carcinoma (HCC) risk-scores may predict HCC in Asian entecavir (ETV)-treated patients. We aimed to study risk factors and performance of risk scores during ETV treatment in an ethnically diverse Western population.
Methods
We studied all HBV monoinfected patients treated with ETV from 11 European referral centres within the VIRGIL Network.
Results
A total of 744 patients were included; 42% Caucasian, 29% Asian, 19% other, 10% unknown. At baseline, 164 patients (22%) had cirrhosis. During a median follow-up of 167 (IQR 82–212) weeks, 14 patients developed HCC of whom nine (64%) had cirrhosis at baseline. The 5-year cumulative incidence rate of HCC was 2.1% for non-cirrhotic and 10.9% for cirrhotic patients (p<0.001). HCC incidence was higher in older patients (p<0.001) and patients with lower baseline platelet counts (p=0.02). Twelve patients who developed HCC …
学术搜索中的文章
P Arends, MJ Sonneveld, R Zoutendijk, I Carey… - Gut, 2015
P Arends, MJ Sonneveld, R Zoutendijk, I Carey… - Gut, 2015