作者
Margaret N Kosek, Tahmeed Ahmed, Zulfiquar Bhutta, Laura Caulfield, Richard Guerrant, Eric Houpt, Gagandeep Kang, Margaret Kosek, Gwenyth Lee, Aldo Lima, Benjamin JJ McCormick, James Platts-Mills, Jessica Seidman, Rebecca R Blank, Michael Gottlieb, Stacey L Knobler, Dennis R Lang, Mark A Miller, Karen H Tountas, Zulfiqar A Bhutta, William Checkley, Richard L Guerrant, Carl J Mason, Laura E Murray-Kolb, William A Petri, Jessica C Seidman, Pascal Bessong, Rashidul Haque, Sushil John, Aldo AM Lima, Estomih R Mduma, Reinaldo B Oriá, Prakash Sunder Shrestha, Sanjaya Kumar Shrestha, Erling Svensen, Anita KM Zaidi, Cláudia B Abreu, Angel Mendez Acosta, Imran Ahmed, AM Shamsir Ahmed, Asad Ali, Ramya Ambikapathi, Leah Barrett, Aubrey Bauck, Eliwaza Bayyo, Ladaporn Bodhidatta, Anuradha Bose, J Daniel Carreon, Ram Krishna Chandyo, Vivek Charu, Hilda Costa, Rebecca Dillingham, Alessandra Di Moura, Viyada Doan, Jose Quirino Filho, Jhanelle Graham, Christel Hoest, Iqbal Hossain, Munirul Islam, M Steffi Jennifer, Shiny Kaki, Beena Koshy, Álvaro M Leite, Noélia L Lima, Bruna LL Maciel, Mustafa Mahfuz, Cloupas Mahopo, Angelina Maphula, Monica McGrath, Archana Mohale, Milena Moraes, Francisco S Mota, Jayaprakash Muliyil, Regisiana Mvungi, Gaurvika Nayyar, Emanuel Nyathi, Maribel Paredes Olortegui, Reinaldo Oria, Angel Orbe Vasquez, William K Pan, John Pascal, Crystal L Patil, Laura Pendergast, Silvia Rengifo Pinedo, Stephanie Psaki, Mohan Venkata Raghava, Karthikeyan Ramanujam, Muneera Rasheed, Zeba A Rasmussen, Stephanie A Richard, Anuradha Rose, Reeba Roshan, Barbara Schaefer, Rebecca Scharf, Srujan L Sharma, Binob Shrestha, Rita Shrestha, Suzanne Simons, Alberto M Soares, Rosa MS Mota, Sajid Soofi, Tor Strand, Fahmida Tofail, Rahul J Thomas, Ali Turab, Manjeswori Ulak, Vivian Wang, Ladislaus Yarrot, Pablo Peñataro Yori, Didar Alam, Caroline Amour, Cesar Banda Chavez, Sudhir Babji, Rosa Rios de Burga, Julian Torres Flores, Jean Gratz, Ajila T George, Dinesh Hariraju, Alexandre Havt, Priyadarshani Karunakaran, Robin P Lazarus, Ila F Lima, Dinesh Mondal, Pedro HQS Medeiros, Rosemary Nshama, Josiane Quetz, Shahida Qureshi, Sophy Raju, Anup Ramachandran, Rakhi Ramadas, A Catharine Ross, Mery Siguas Salas, Amidou Samie, Kerry Schulze, E Shanmuga Sundaram, Buliga Mujaga Swema, Dixner Rengifo Trigoso
发表日期
2017/4/1
期刊
EBioMedicine
卷号
18
页码范围
109-117
出版商
Elsevier
简介
Background
Environmental enteropathy (EE), the adverse impact of frequent and numerous enteric infections on the gut resulting in a state of persistent immune activation and altered permeability, has been proposed as a key determinant of growth failure in children in low- and middle-income populations. A theory-driven systems model to critically evaluate pathways through which enteropathogens, gut permeability, and intestinal and systemic inflammation affect child growth was conducted within the framework of the Etiology, Risk Factors and Interactions of Enteric Infections and Malnutrition and the Consequences for Child Health and Development (MAL-ED) birth cohort study that included children from eight countries.
Methods
Non-diarrheal stool samples (N=22,846) from 1253 children from multiple sites were evaluated for a panel of 40 enteropathogens and fecal concentrations of myeloperoxidase, alpha-1 …
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MN Kosek, T Ahmed, Z Bhutta, L Caulfield, R Guerrant… - EBioMedicine, 2017