作者
Jian Lu, Michael J Matunis
发表日期
2013/12
期刊
Nature structural & molecular biology
卷号
20
期号
12
页码范围
1346-1348
出版商
Nature Publishing Group US
简介
Mediator of DNA-damage checkpoint 1 (MDC1) has a central role in repair of DNA double-strand breaks (DSBs) by both homologous recombination and nonhomologous end joining, and its function is regulated by post-translational phosphorylation, ubiquitylation and SUMOylation. In this issue, a new study by Watanabe et al. reveals that methylation of MDC1 is also critical for its function in DSB repair and specifically affects repair through BRCA1-dependent homologous recombination.
学术搜索中的文章
J Lu, MJ Matunis - Nature structural & molecular biology, 2013