作者
Arash Navran, Wilma Heemsbergen, Tomas Janssen, Olga Hamming-Vrieze, Marcel Jonker, Charlotte Zuur, Marcel Verheij, Peter Remeijer, Jan-Jakob Sonke, Michiel van den Brekel, Abrahim Al-Mamgani
发表日期
2019/1/1
期刊
Radiotherapy and oncology
卷号
130
页码范围
25-31
出版商
Elsevier
简介
Background and purpose
In recent decades, outcomes of patients with head and neck cancer (HNC) have improved as a result of implementing several strategies, such as chemoradiation. However, these improvements were achieved at the cost of increased toxicity. One way to reduce radiation-related toxicity is by reducing the margins.
Materials and methods
Between 2013 and 2016, 206 consecutive patients were treated with CTV-PTV margin of 5 mm and subsequently 208 patients with 3 mm margin. This study evaluates the impact of reducing clinical target volume (CTV) to planning target volume (PTV) margin on outcome and toxicity.
Results
All patients were treated with volumetric modulated arc therapy (VMAT) with daily-image guidance using cone-beam CT (CBCT). Overall acute grade 3 toxicity was significantly lower in 3 mm-group, compared to 5 mm-group (53.8% vs. 65%, respectively, p = 0.032 …
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A Navran, W Heemsbergen, T Janssen… - Radiotherapy and oncology, 2019