作者
Esther ND Kok, Edwin PM Jansen, Birthe C Heeres, Niels FM Kok, Tomas Janssen, Erik van Werkhoven, Fay RK Sanders, Theodore JM Ruers, Marlies E Nowee, Koert FD Kuhlmann
发表日期
2020/1/1
期刊
Clinical and translational radiation oncology
卷号
20
页码范围
45-50
出版商
Elsevier
简介
Introduction
Stereotactic Body Radiation Therapy (SBRT) is a treatment option for patients with liver metastases. This study evaluated the impact of high versus low dose image-guided SBRT of hepatic metastases.
Methods and materials
This is a single-center retrospective study of patients with liver metastases treated with SBRT. For analyses, patients were divided into two groups: ≤100 Gy and >100 Gy near-minimum Biological Effective Doses (BED98%). The main outcomes were local control (LC), toxicity and overall survival (OS). Cox regression analyses were performed to determine prognostic variables on LC and OS.
Results
Ninety patients with 97 liver metastases (77% colorectal) were included. Median follow-up was 28.6 months. The two-year LC rates in the ≤100 Gy and >100 Gy BED98% group were 60% (CI: 41–80%) and 90% (CI: 80–100%), respectively (p = 0.004). Grade 3 toxicity occurred in 7% vs 2 …
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END Kok, EPM Jansen, BC Heeres, NFM Kok… - Clinical and translational radiation oncology, 2020