作者
Marta Guasch-Ferré, Miguel Ruiz-Canela, Jun Li, Yan Zheng, Mònica Bulló, Dong D Wang, Estefanía Toledo, Clary Clish, Dolores Corella, Ramon Estruch, Emilio Ros, Montserrat Fitó, Fernando Arós, Miquel Fiol, José Lapetra, Lluís Serra-Majem, Liming Liang, Christopher Papandreou, Courtney Dennis, Miguel A Martínez-González, Frank B Hu, Jordi Salas-Salvadó
发表日期
2019/5
期刊
The Journal of Clinical Endocrinology & Metabolism
卷号
104
期号
5
页码范围
1508-1519
出版商
Endocrine Society
简介
Context
The potential associations between acylcarnitine profiles and incidence of type 2 diabetes (T2D) and whether acylcarnitines can be used to improve diabetes prediction remain unclear.
Objective
To evaluate the associations between baseline and 1-year changes in acylcarnitines and their diabetes predictive ability beyond traditional risk factors.
Design, Setting, and Participants
We designed a case-cohort study within the PREDIMED Study including all incident cases of T2D (n = 251) and 694 randomly selected participants at baseline (follow-up, 3.8 years). Plasma acylcarnitines were measured using a targeted approach by liquid chromatography–tandem mass spectrometry. We tested the associations between baseline and 1-year changes in individual acylcarnitines and T2D risk using weighted Cox regression models. We used elastic net …
学术搜索中的文章
M Guasch-Ferré, M Ruiz-Canela, J Li, Y Zheng, M Bulló… - The Journal of Clinical Endocrinology & Metabolism, 2019