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The most efficient way of maintaining a desired drug effect is by continuous infusion to attain constant blood concentrations. Dose regimens that compensate for drug distribution as well as for excretion, can achieve and maintain targeted concentrations by using pharmacokinetic simulations. These target-controlled infusions (TCI) can be administered by computer control using syringe pumps that have inbuilt TCI software, or by manual control, using simulation software that calculates and displays expected drug concentrations. Clinicians now need to associate blood concentrations with expected effects, but fortunately, this is familiar to anaesthetists who relate alveolar partial pressures of inhaled anaesthetic to drug effect. TCI facilitates fine-tuning of drug concentrations according to patient requirements in similar fashion to a vaporizer. The speed with which patients recover after intravenous infusions is influenced …