作者
Gerben Hulsegge, Gerrie‐Cor M Herber‐Gast, Annemieke MW Spijkerman, H Susan, J Picavet, Yvonne T van der Schouw, Stephan JL Bakker, Ron T Gansevoort, Martijn ET Dollé, Henriette A Smit, WM Monique Verschuren
发表日期
2016/6
期刊
Obesity
卷号
24
期号
6
页码范围
1389-1396
简介
Objective
The prevalence of obesity increases with age and is higher in each younger generation (unfavorable generation shift). This may influence patterns of oxidative stress and inflammation. Age‐related changes and generation shifts in markers of oxidative stress and inflammation were investigated, specifically addressing the role of body mass index (BMI).
Methods
Four generations (aged 26–35, 36–45, 46–55, and 56–65 at baseline) (N = 5,155) were examined every 5 years for 15 years between 1993 and 2012. Random coefficient analyses were used to study age‐related changes and generation shifts in BMI, γ‐glutamyltransferase (GGT), uric acid (UA), and C‐reactive protein (CRP).
Results
Levels of BMI, UA, and CRP increased in all generations up to age 75, whereas GGT increased up to age 55. No consistent generation shifts were observed for GGT, UA, and CRP (P ≥ 0.05). Participants with a …
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G Hulsegge, GCM Herber‐Gast, AMW Spijkerman… - Obesity, 2016