作者
Seham El-Kassas, Odemuyiwa Solomon, George Hajishengallis, Terry D Connell, Toufic O Nashar
发表日期
2016/12
期刊
Journal of Clinical & Cellular Immunology
卷号
7
期号
6
出版商
OMICS International
简介
Cholecystokinin (CCK) is a neuropeptide that affects growth rate in chickens by regulating appetite. CCK peptides exert their function by binding to two identified receptors, CCKAR and CCKBR in the GI tract and the brain, respectively, as well as in other organs. In mammals, CCK/CCKAR interactions affect a number of immunological parameters, including regulation of lymphocytes and functioning of monocytes. Thus, food intake and growth can potentially be altered by infection and the resulting inflammatory immune response. It is uncertain, however, whether chicken express CCKAR in immune organs and cells, and, if so, whether CCKAR expression is regulated by pathogen derived inflammatory stimuli. Herein, we identify expression of CCKAR protein in chicken peripheral blood mononuclear cells (PBMC) including monocytes, and expression of the CCKAR gene in PBMC, thymus, bursa, and spleen, in …
学术搜索中的文章
S El-Kassas, S Odemuyiwa, G Hajishengallis… - Journal of clinical & cellular immunology, 2016