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It is well known that Src tyrosine kinase, insulin‐like growth factor 1 receptor (IGF‐IR), and focal adhesion kinase (FAK) play important roles in prostate cancer (PrCa) development and progression. Src, which signals through FAK in response to integrin activation, has been implicated in many aspects of tumor biology, such as cell proliferation, metastasis, and angiogenesis. Furthermore, Src signaling is known to crosstalk with IGF‐IR, which also promotes angiogenesis. In this study, we demonstrate that c‐Src, IGF‐IR, and FAK are packaged into exosomes (Exo), c‐Src in particular being highly enriched in Exo from the androgen receptor (AR)‐positive cell line C4‐2B and AR‐negative cell lines PC3 and DU145. Furthermore, we show that the active phosphorylated form of Src (Src^pY416) is co‐expressed in Exo with phosphorylated FAK (FAK^pY861), a known target site of Src, which enhances proliferation and …