作者
Jerônimo C Ruiz, Vívian D'Afonseca, Artur Silva, Amjad Ali, Anne C Pinto, Anderson R Santos, Aryanne AMC Rocha, Débora O Lopes, Fernanda A Dorella, Luis GC Pacheco, Marcília P Costa, Meritxell Z Turk, Núbia Seyffert, Pablo MRO Moraes, Siomar C Soares, Sintia S Almeida, Thiago LP Castro, Vinicius AC Abreu, Eva Trost, Jan Baumbach, Andreas Tauch, Maria Paula C Schneider, John McCulloch, Louise T Cerdeira, Rommel TJ Ramos, Adhemar Zerlotini, Anderson Dominitini, Daniela M Resende, Elisângela M Coser, Luciana M Oliveira, André L Pedrosa, Carlos U Vieira, Cláudia T Guimarães, Daniela C Bartholomeu, Diana M Oliveira, Fabrício R Santos, Élida Mara Rabelo, Francisco P Lobo, Glória R Franco, Ana Flávia Costa, Ieso M Castro, Sílvia Regina Costa Dias, Jesus A Ferro, José Miguel Ortega, Luciano V Paiva, Luiz R Goulart, Juliana Franco Almeida, Maria Inês T Ferro, Newton P Carneiro, Paula RK Falcão, Priscila Grynberg, Santuza MR Teixeira, Sérgio Brommonschenkel, Sérgio C Oliveira, Roberto Meyer, Robert J Moore, Anderson Miyoshi, Guilherme C Oliveira, Vasco Azevedo
发表日期
2011/4/18
期刊
PloS one
卷号
6
期号
4
页码范围
e18551
出版商
Public Library of Science
简介
Background
Corynebacterium pseudotuberculosis, a Gram-positive, facultative intracellular pathogen, is the etiologic agent of the disease known as caseous lymphadenitis (CL). CL mainly affects small ruminants, such as goats and sheep; it also causes infections in humans, though rarely. This species is distributed worldwide, but it has the most serious economic impact in Oceania, Africa and South America. Although C. pseudotuberculosis causes major health and productivity problems for livestock, little is known about the molecular basis of its pathogenicity.
Methodology and Findings
We characterized two C. pseudotuberculosis genomes (Cp1002, isolated from goats; and CpC231, isolated from sheep). Analysis of the predicted genomes showed high similarity in genomic architecture, gene content and genetic order. When C. pseudotuberculosis was compared with other Corynebacterium species, it became evident that this pathogenic species has lost numerous genes, resulting in one of the smallest genomes in the genus. Other differences that could be part of the adaptation to pathogenicity include a lower GC content, of about 52%, and a reduced gene repertoire. The C. pseudotuberculosis genome also includes seven putative pathogenicity islands, which contain several classical virulence factors, including genes for fimbrial subunits, adhesion factors, iron uptake and secreted toxins. Additionally, all of the virulence factors in the islands have characteristics that indicate horizontal transfer.
Conclusions
These particular genome characteristics of C. pseudotuberculosis, as well as its …
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JC Ruiz, V D'Afonseca, A Silva, A Ali, AC Pinto… - PloS one, 2011
