作者
Eva Trost, Lisa Ott, Jessica Schneider, Jasmin Schröder, Sebastian Jaenicke, Alexander Goesmann, Peter Husemann, Jens Stoye, Fernanda Alves Dorella, Flavia Souza Rocha, Siomar de Castro Soares, Vívian d'Afonseca, Anderson Miyoshi, Jeronimo Ruiz, Artur Silva, Vasco Azevedo, Andreas Burkovski, Nicole Guiso, Olivier F Join-Lambert, Samer Kayal, Andreas Tauch
发表日期
2010/12
期刊
BMC genomics
卷号
11
页码范围
1-17
出版商
BioMed Central
简介
Background
Corynebacterium pseudotuberculosis is generally regarded as an important animal pathogen that rarely infects humans. Clinical strains are occasionally recovered from human cases of lymphadenitis, such as C. pseudotuberculosis FRC41 that was isolated from the inguinal lymph node of a 12-year-old girl with necrotizing lymphadenitis. To detect potential virulence factors and corresponding gene-regulatory networks in this human isolate, the genome sequence of C. pseudotuberculosis FCR41 was determined by pyrosequencing and functionally annotated.
Results
Sequencing and assembly of the C. pseudotuberculosis FRC41 genome yielded a circular chromosome with a size of 2,337,913 bp and a mean G+C content of 52.2%. Specific gene sets associated with iron and zinc homeostasis were detected among the 2,110 predicted …
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E Trost, L Ott, J Schneider, J Schröder, S Jaenicke… - BMC genomics, 2010