作者
Maria Tikhonenko, Todd A Lydic, Yun Wang, Weiqin Chen, Madalina Opreanu, Andrew Sochacki, Kelly M McSorley, Rebecca L Renis, Timothy Kern, Donald B Jump, Gavin E Reid, Julia V Busik
发表日期
2010/1/1
期刊
Diabetes
卷号
59
期号
1
页码范围
219-227
出版商
American Diabetes Association
简介
OBJECTIVE
The results of the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications cohort study revealed a strong association between dyslipidemia and the development of diabetic retinopathy. However, there are no experimental data on retinal fatty acid metabolism in diabetes. This study determined retinal-specific fatty acid metabolism in control and diabetic animals.
RESEARCH DESIGN AND METHODS
Tissue gene and protein expression profiles were determined by quantitative RT-PCR and Western blot in control and streptozotocin-induced diabetic rats at 3–6 weeks of diabetes. Fatty acid profiles were assessed by reverse-phase high-performance liquid chromatography, and phospholipid analysis was performed by nano-electrospray ionization tandem mass spectrometry.
RESULTS
We found a dramatic …
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M Tikhonenko, TA Lydic, Y Wang, W Chen, M Opreanu… - Diabetes, 2010