作者
Jennifer L Kielczewski, Yagna PR Jarajapu, Evan L McFarland, Jun Cai, Aqeela Afzal, Sergio Li Calzi, Kyung Hee Chang, Todd Lydic, Lynn C Shaw, Julia Busik, Jeffrey Hughes, Arturo J Cardounel, Kenneth Wilson, Timothy J Lyons, Michael E Boulton, Robert N Mames, Tailoi Chan-Ling, Maria B Grant
发表日期
2009/10/23
期刊
Circulation research
卷号
105
期号
9
页码范围
897-905
出版商
Lippincott Williams & Wilkins
简介
Rationale: Insulin-like growth factor binding protein (IGFBP)-3 modulates vascular development by regulating endothelial progenitor cell (EPC) behavior, specifically stimulating EPC cell migration. This study was undertaken to investigate the mechanism of IGFBP-3 effects on EPC function and how IGFBP-3 mediates cytoprotection following vascular injury.
Objective: To examine the mechanism of IGFBP-3–mediated repair following vascular injury.
Methods and Results: We used 2 complementary vascular injury models: laser occlusion of retinal vessels in adult green fluorescent protein (GFP) chimeric mice and oxygen-induced retinopathy in mouse pups. Intravitreal injection of IGFBP-3–expressing plasmid into lasered GFP chimeric mice stimulated homing of EPCs, whereas reversing ischemia induced increases in macrophage infiltration. IGFBP-3 also reduced the retinal ceramide/sphingomyelin ratio that …
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JL Kielczewski, YPR Jarajapu, EL McFarland, J Cai… - Circulation research, 2009