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Diabetes is a dangerous disease caused by the inability of the body to produce and use insulin properly, resulting in an increase in the blood glucose level. The most advanced technology for glucose detection is the surface plasmon resonance (SPR)-based sensor. However, this technology has a slight drawback due to the small size of glucose. As a porous material, Zr-based UiO-66 MOF has good adsorption with glucose via hydrogen bonding, so it can be utilized as a receptor and active layer for the SPR glucose sensor, without the need for other receptors, such as glucose oxidase, concanavalin A, or boronic acid-based compounds. This study investigates the morphology effect, immobilization techniques, and signal amplification strategies for optimizing the utilization of UiO-66 in the SPR glucose sensor. By optimizing these parameters, a high-performance SPR glucose sensor with a detection limit of 0.0693 …