作者
Ester Carreño, Amalia Enríquez‐de‐Salamanca, Marisa Tesón, Carmen García‐Vázquez, Michael E Stern, Scott M Whitcup, Margarita Calonge
发表日期
2010/11/1
期刊
Acta ophthalmologica
卷号
88
期号
7
页码范围
e250-e258
出版商
Blackwell Publishing Ltd
简介
Acta Ophthalmol. 2010: 88: e250–e258
Abstract
Purpose: There is growing evidence for the existence of an ‘immune tone’ in normal tears. The aim of this study was to determine the levels of a large panel of cytokines and chemokines in tears obtained from healthy subjects. These levels can then serve as baseline values for comparison with patients suffering from ocular surface diseases.
Subjects and Methods: Nine healthy subjects participated in this study, and normal ocular surface health was documented by the results of a dry eye questionnaire, Schirmer strip wetting, and vital staining of the cornea. Four microliters of tears were collected from each eye and analysed separately with multiplex bead‐based assays for the concentration of 30 cytokines and chemokines.
Results: Twenty‐five cytokines/chemokines were detected. CCL11/Eotaxin1, GM‐CSF, G‐CSF, IFN‐γ, IL‐2, IL‐3, IL‐4, IL‐5, IL‐10, IL‐13, IL …
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E Carreño, A Enríquez‐de‐Salamanca, M Tesón… - Acta ophthalmologica, 2010