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To determine whether the levels of cytokines and chemokines in tears differ in uveitis patients and healthy subjects.

Ninety‐two uveitis patients (mean age 46.4 years) and 157 control healthy subjects (mean age 49.5 years) were recruited. Subjects with ocular surface diseases such as dry eye were excluded from the study. Using multiplex bead‐based assays, tears (4 μl) were analysed for the concentration of interleukin (IL)‐1β, IL‐1RA, IL‐2, IL‐6, IL‐7, IL‐8/CXCL8, IL‐10, IL‐12p70, IL‐15, IL‐17A, IL‐23, epidermal growth factor (EGF), fractalkine/CX3CL1, interferon‐γ, IP‐10/CXCL10, monocyte chemo‐attractant protein (MCP)‐1/CCL2, tumour necrosis factor‐α, vascular endothelial growth factor (VEGF), transforming growth factor (TGF)‐β1, TGF‐β2 and TGF‐β3. Tear molecule levels were compared between the groups and among the different forms of uveitis and disease severity.